The use of the pulsed laser ablation method is proposed for obtaining solutions based on Dy2O3-nanoparticles for T2 MRI contrast agents at high magnetic fields. It has been demonstrated that the PLA method can help simplify and shorten the duration of obtaining stable Dy2O3 nanoparticle-based colloids, the relaxivity of which exceeds the relaxivity values of commercially-available MRI contrast agents.