Medical implants which include a local drug delivery system are a growing area in implant development. For many implant applications silicone is used as material because of its chemical inertness and good biological performance. However the choice of silicone as material brings up some challenges when a local drug delivery system should be applied. To enhance adhesion of a drug containing polymeric coating silicone was activated by aid of plasma chemistry. This treatment leads to reactive groups which can be used for further modification. After an additional treatment with 3-Aminopropyl-triethoxysilane (APTS) polymers activated by 1-[3-Dimethylamino)propyl]-3-ethylcarbo-diimide hydrochloride (EDC) were coupled to the surface to give a polymeric monolayer. Afterwards a polymer coating with Dexamethasone incorporation was applied to the silicone by a spray coating technique. Coatings on the basis of PLLA and P(4HB) show an increased mechanical stability. Investigations on the release of Dexamethasone from these coatings show as well that the conducted work is a good basis for further developments.