Hybrid components, made of multiple materials, can meet the increasing demands for lightweight construction and functional integration in the automotive and aircraft industry. Hybrid semi-finished components are produced by applying a high-alloy cladding to a low-alloy base material before hot-forming and machining the workpiece. Throughout this process chain, workpiece deviations in the form of material distribution and material properties can occur that influence the component’s lifetime. This paper investigates whether such workpiece deviations can be detected within the process chain by analyzing process signals obtained from subsequent process steps. For this purpose, artificial workpiece deviations were introduced to hybrid semi-finished workpieces made of C22.8/X45CrSi9-3. Then, process signals during forming and machining were analyzed to determine their sensitivity to the artificial deviations. The results revealed that deviations in cladding size can be effectively monitored using signals from both forming and machining. Cladding position deviations can only be detected during machining, while forming signals are more responsive to detecting the introduced hardness deviations of approx. 100 HV0.1.