We report on high-order-harmonic generation from micrometer-sized liquid water droplets. In pump-probe experiments, the influence of the time delay onto the emission of harmonic radiation is systematically studied. Phase-matching aspects are observed by controlling the focal position and the intensity of the probe pulse. The spatiotemporal dynamics of the droplet during interaction with intense laser pulses are studied by controlling the intensity of the pump pulse. We find transient phase-matching conditions and the expansion dynamics of the droplet to be of major influence on the harmonic yield.