The success of an implant depends on its perfect integration into the surrounding tissue - addressing guided and selective cell responses. For this purpose, material functionalization methods are under development. All strategies have in common that fibrous tissue has to be reduced, since it leads to implant failure. At the same time, competitive cells like neuronal cells have to be stimulated. One functionalization approach focuses on the fabrication of defined surface topographies. In this demand laser-processing or microreplication technique enable the production of different surface features with controllable dimensions in various materials. Here, laser-generated self-organized nanostructures in platinum were used to study topographical effects on cell behaviour. The topography itself consisted of a nano-roughness, which was wave-like distributed over the entire surface. Addressing cell alignment, morphology and proliferation we show that the structures control selectively the responses of fibroblasts and neuroblastoma cells. Neuroblastoma cells were orientated and smaller in cell size. Additionally, their cell growth was not negatively affected. Fibroblasts adhered ?wave-like? - corresponding with the surface texturing - and randomly on the structures and were elongated. At the same time, proliferation of fibroblasts was significantly reduced. These findings suggest that nanostructures in platinum are favourable topographies for electronic devices enabling selective cell control.