3D printing is one of the key technologies in space exploration. The disparity in gravitational forces between Earth and space presents both challenges and opportunities with regard to material handling. This article examines the potential of employing ultrasonic levitation as a handling tool for substrate-free additive manufacturing processes in microgravity environments. Through preliminary experiments, we demonstrate the feasibility of manipulating polymer powders using acoustic fields while concurrently melting the levitated material. Subsequent experiments conducted in our drop tower facility confirm our ability to manipulate particles with acoustic traps under microgravity conditions. Building upon these findings, we outline plans to further advance our research using an expanded acoustic levitation system capable of three-dimensional object manipulation. Our objectives include moving and orienting large components beyond the wavelength limit in microgravity, manipulating granular raw material while melting it in proximity to the print part, and achieving a semi-continuous fusion of print material with the print part. Therefore, we present an intelligent control strategy based on the results of a digital twin simulation. Furthermore, we utilize a stereo camera combined with computer vision as feedback for the control system to ensure precise handling of the manipulated objects and particles. This study represents a significant advance toward the realization of efficient substrate-free additive manufacturing processes in microgravity environments, with potential applications for in-space manufacturing. Ultimately, this could result in long-term space missions becoming less reliant on supply deliveries, thus reducing cost and additionally enabling faster response to unforeseen issues.